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Clinically, these TKIs account cardiovascular toxicities together with hypertension, affection failure, and QT assiduity . The VEGFR2/PDGFR-inhibiting TKIs sorafenib, regorafenib, and ponatinib induced the achieved ranges of cytotoxicity in hiPSC-ECs, hiPSC-CFs, and hiPSC-CMs alike. The aerial hiPSC-EC toxicity we empiric with VEGFR2/PDGFR-inhibiting TKIs such as ponatinib is fixed with the vascular toxicity empiric clinically with these TKIs . The cytotoxicity contour for akin hiPSCs was essentially tailored from that of hiPSC-derived cardiovascular derivatives. For instance, the VEGFR2/PDGFR inhibitor axitinib was the atomic cytotoxic TKI in hiPSC-CMs.
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